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In enzymology, a 2-dehydro-3-deoxy-phosphogluconate aldolase (), commonly known as KDPG aldolase, is an enzyme that catalyzes the chemical reaction :2-dehydro-3-deoxy-D-gluconate 6-phosphate pyruvate + D-glyceraldehyde 3-phosphate Hence, this enzyme primarily has one substrate, 2-dehydro-3-deoxy-D-gluconate 6-phosphate, and two products, pyruvate and D-glyceraldehyde 3-phosphate. This enzyme belongs to the family of lyases, specifically the aldehyde-lyases, which cleave carbon-carbon bonds. It is used in the Entner–Doudoroff pathway in prokaryotes, feeding into glycolysis. 2-dehydro-3-deoxy-phosphogluconate aldolase is one of the two enzymes distinguishing this pathway from the more commonly known Embden–Meyerhof–Parnas pathway. This enzyme also participates in following 3 metabolic pathways: pentose phosphate pathway, pentose and glucuronate interconversions, and arginine and proline metabolism. In addition to the cleavege of 2-dehydro-3-deoxy-D-gluconate 6-phosphate, it is also found to naturally catalyze Schiff base formation between a lysine E-amino acid group and carbonyl compounds, decarboxylation of oxaloacetate, and exchange of solvent protons with the methyl hydrogen atoms of pyruvate.〔 ==Nomenclature== The systematic name of this enzyme class is 2-dehydro-3-deoxy-D-gluconate-6-phosphate D-glyceraldehyde-3-phosphate-lyase (pyruvate-forming). Other names in common use include: * KDPG aldolase * phospho-2-keto-3-deoxygluconate aldolase * phospho-2-keto-3-deoxygluconic aldolase * 2-keto-3-deoxy-6-phosphogluconic aldolase * 2-keto-3-deoxy-6-phosphogluconate aldolase * 6-phospho-2-keto-3-deoxygluconate aldolase * ODPG aldolase, 2-oxo-3-deoxy-6-phosphogluconate aldolase * 2-keto-3-deoxygluconate-6-P-aldolase * 2-keto-3-deoxygluconate-6-phosphate aldolase * 2-dehydro-3-deoxy-D-gluconate-6-phosphate * D-glyceraldehyde-3-phosphate-lyase 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「2-dehydro-3-deoxy-phosphogluconate aldolase」の詳細全文を読む スポンサード リンク
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